204 papers
Cancer biology explores the complex ways cells grow out of control, investigating the genetic mutations and environmental factors that drive tumor formation. This field seeks to understand how healthy cells transform into malignant ones and how these rogue cells spread throughout the body. By decoding these fundamental mechanisms, researchers aim to develop more effective treatments that target the disease at its source while sparing healthy tissue.
At Gist.Science, we process every new preprint published in this category directly from bioRxiv to ensure you stay ahead of the curve. Our team provides both accessible plain-language overviews and detailed technical summaries for each study, bridging the gap between raw research data and practical understanding. Whether you are a specialist or a curious reader, our goal is to make these critical findings clear and actionable.
Below are the latest papers in cancer biology, offering fresh insights into the ongoing fight against this disease.
This study identifies EZH1 upregulation as a resistance mechanism to PI3K inhibition in acute myeloid leukemia leukemic stem cells and demonstrates that combining a PI3K inhibitor with an EZH1/2 dual inhibitor overcomes this resistance to effectively target the disease in preclinical models.
This study utilizes single-cell and multi-omics analyses to reveal that while BRCA1 and BRCA2 somatic mutations in lung adenocarcinoma drive distinct transcriptional programs and immune microenvironment alterations—such as differential T cell activation and tissue-resident memory T cell expansion—they collectively predict improved responses to immune checkpoint blockade despite being associated with genomic instability and poor prognosis.
This study reveals that antibodies against a specific enterovirus epitope (CE1) protect against hepatocellular carcinoma by cross-reacting with the tumor-associated protein ASPH via molecular mimicry, thereby triggering NK cell-mediated tumor destruction.
This study demonstrates that extracellular signaling induces phosphorylation of Menin at Ser487, which restricts its nuclear accumulation and relieves transcriptional repression of gastrin, thereby contributing to neuroendocrine tumorigenesis.
Through CRISPR screening and epigenomic analysis, this study identifies POU2F1 as a critical, context-specific transcriptional activator of DLL3 and neuroendocrine identity in small cell lung cancer, operating via a tandem cis-regulatory code with ASCL1.
This study reveals that the HPV E7 oncoprotein drives LASP1 transcription in HPV-positive cervical cancer cells by degrading Rb to activate E2F1, which directly binds to and promotes the LASP1 promoter, thereby establishing an additional mechanism alongside miR-203 downregulation that underscores LASP1's critical role in cancer progression.
This study demonstrates that patient-derived lung cancer organoids successfully replicate the unique histological features, including keratin pearl structures and specific tumor markers, of their parent keratinizing squamous cell carcinomas, establishing them as high-fidelity 3D models for advancing preclinical drug testing and understanding tumor biology.
This study identifies that SIRT5 overexpression in triple-negative breast cancer drives chemoresistance by orchestrating a metabolic switch that enhances nucleotide production and oxidative phosphorylation, while simultaneously creating a therapeutic vulnerability to ATR inhibition due to induced replication stress.
This study reveals that multiple myeloma and its treatments, including autologous stem cell transplant, durably reshape the bone marrow niche to impair immune reconstitution and vaccine responses, a defect that can be overcome by lipid nanoparticle-adjuvanted mRNA vaccines.
This study presents a scalable ex vivo platform using decellularized mouse organ scaffolds that preserves native tissue-specific matrix cues to accurately recapitulate organ-selective cancer cell invasion patterns, offering a cost-effective alternative to in vivo models for studying metastasis and testing therapies.